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Mislocalized calcium channel causes insulin secretion defect in diabetes


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The cellular signal for insulin secretion is an influx of calcium, which triggers the release of small hormone-containing storage vesicles. Recent work from Sebastian Barg’s lab at Uppsala University, in collaboration with researchers from Padua, Oxford, and the NIH, now indicates that a tiny change in the cells’ architecture is at the heart of the secretion defect.

Key Takeaways:

  • In people with diabetes this mechanism fails, which leads to elevated blood sugar and a host of other diabetes related complications.
  • The cellular signal for insulin secretion is an influx of calcium, which triggers the release of small hormone-containing storage vesicles.
  • In type-2 diabetes, the channel proteins that allow calcium the entry are instead located too far away from the insulin vesicles, which causes secretion to fail.

“intricate relationship between the insulin secretion machinery and calcium channels”

https://www.sciencedaily.com/releases/2017/05/170519083937.htm