Cholecalciferol in high dose has a marked antidepressant-like effect in the adult female rats with low levels of estrogen.

The world today has become a busy and often unrelenting place. This has caused the number of cases of depression to greatly increase over the years. Depression and ways to treat it has become the focus of many research groups. One preclinical study has been testing the effects of cholecalciferol in rats that had undergone ovariectomies. It was found that the drug had an anti-depressant effect that greatly lowered levels of corticosterone in the rats, which can be an indicator of depression and was increased previous to the administration of the drug.

Cholecalciferol in high dose has a marked antidepressant-like effect in the adult female rats with low levels of estrogen.

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