Vitamin D insufficiency is a common risk factor for osteoporosis associated with increased bone remodelling and low bone mass.

While Vitamin D insufficiency is a risk factor for osteoporosis, a 2016 study found that there is no correlation between 25(OH)D levels and bone mineral density (BMD). The study used 100 post-menopausal women which were subjected to x-rays in order to determine bone mineral density. While there was no correlation found, it was found Vitamin D deficiency exists side-by-side with low BMD.

Key Takeaways:

  • A total of 100 healthy PMW were selected, and a prospective observational study was conducted to correlate the BMD with serum 25(OH)D levels.
  • Their laboratory investigations along with serum 25(OH)D levels were done. Their BMD was assessed with dual-energy X-ray absorptiometry at lumbar spine and neck of femur; T-scores were derived.
  • Correlation analysis was done to investigate the relationship between serum 25(OH)D levels and BMD.

“In this study, among our cohort of patients there was no correlation between serum 25(OH)D levels and BMD. However, Vitamin D deficiency coexists with low BMD.”