Skin Aging Update

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Free radical activity in the upper layer of the skin is a leading cause of skin aging. Alpha-glycolic acid, vitamin E, and melatonin were applied topically to monitor the anti-aging effects in different skin layers in a study published in Biochemistry and Molecular Biology International. When applied together, melatonin, vitamin E, and alpha-glycolic acid become more effective than when applied separately. The antioxidant activity of vitamin E increases the effect of glycolic acid on epidermal turnover, while glycolic acid increases the effect of melatonin. Some previous studies have indicated that melatonin and vitamin E may be effective at reducing skin damage and aging caused by UV radiation. When these three things were applied to the skin together, there was a bigger benefit than if they were applied separately.

One downside to Retin-A and alpha hydroxy acids is that they can cause skin irritation and inflammation, sometimes appearing as red blotches. A study found that ginkgo biloba extract helps the skin produce more collagen and has anti-inflammatory properties. The irritation some people experience when using products like Renova, Retin-A, and fruit acid compounds can be dramatically reduced by the topical application of ginkgo extract, according to Professor Carmen Fusco.

The study, published in the journal Skin and Allergy News, followed a group of women who applied a cream containing antioxidants and sunscreen to their skin for 18 months. The women in the study who applied sunscreen that contained antioxidants were compared to a placebo group who applied sunscreen that did not contain antioxidants. The results showed that compared to the placebo, the women using the sunscreen plus antioxidant cream:

  • Manifested fewer lines and wrinkles
  • Showed reduced lipid peroxidation to the skin
  • Had greater skin thickness and elasticity

The study showed that solar radiation and environmental pollutants can cause oxidation, which can have adverse effects on the skin. Topically applied antioxidants can help protect the skin when used with sunscreen. This study showed that topically applied antioxidants are better at protecting the skin than antioxidant supplements that are taken orally.

Keeping skin young: a new approach

A new body lotion has been created that includes alpha-glycolic acid, vitamin E, melatonin, and ginkgo. These ingredients are backed by scientific research and over twenty years of clinical experience in using topical nutrients to prevent skin aging. The nutrients in the product work together to suppress free radical damage and inhibit additional mechanisms involved in skin aging, including damage from the sun.

Rejuvenating aged skin

The pioneering work of Benjamin S. Frank, M.D. showed that RNA improved cellular energy and the ability of the skin cells to use oxygen. This research provides new insights into how to improve cellular metabolism and could have important implications for treating a variety of disorders. The text describes how young cells moving to the surface of the skin helps to improve metabolism. Topically-applied RNA can also help to repair damage to early skin cells. Clinical trials by Dr. S.J. In the 1970s, Jellinek showed that creams containing RNA/DNA could visibly lift/tighten skin and reduce the appearance of wrinkles in a three-week period. Although the study was not large, it used a double-blind test. This new body lotion contains RNA and DNA, which help to revitalize your skin cells all over your body.

Alpha glycolic acid is the most effective of the alpha-hydroxy acids at reducing fine wrinkles in aging human skin. Alpha-glycolic acid works by breaking down older cells on the surface of the skin, so that they can be replaced by newer, more youthful cells. A clinical trial at Massachusetts General Hospital showed that topically applied alpha-glycolic acid significantly reduced wrinkling and other types of damage caused by chronic sun exposure. The trial included 74 women over age 40 and lasted 22 weeks. This lotion contains a purified form of alpha-glycolic acid, as well as ginkgo extract and vitamin E to help protect the skin from irritation.

Molecular moisturizers

The primary reason that women use body lotions is to replace the moisture that is lost due to aging. The new Rejuvenex Body Lotion is a glycerid acid moisturizer that contains Ceraphyl GA-D. This ingredient helps to reduce the excessive drying of the upper layers of the skin. Drs. Stig Fribergand David W. Glycerid acid inhibits trans epidermal water loss by preventing lipids from crystallizing. The mechanism prevents your skin from becoming dry, thin, leathery, dull, and wrinkled. The glycerid acid in Rejuvenex Body Lotion not only increases the effectiveness of sunscreens but also makes skin cells more receptive to antioxidants such as vitamins A, C, and E.

Hyaluronic acid has a different mechanism than glycerid acid for helping the skin retain its youthful moisture. Hyaluronic acid helps to keep connective tissue strong and healthy because it provides the body with manganese and glucosamine. Injectable hyaluronic acid may one day replace injectable collagen, but the new Rejuvenex Body Lotion provides abundant quantities of this important skin-preserving nutrient today.

The antioxidant hormone

Melatonin is a hormonal antioxidant that helps protect the skin from oxidative damage. This research group found that melatonin protects against sunburn if applied before exposure to the sun. It seems that melatonin also plays a part in repairing burned skin. According to a study published in the Brain Research Bulletin, melatonin levels increased six hours after a burn injury, then returned to normal. In small amounts, melatonin causes skin cells to proliferate. When applied to the skin, it seems to have better anti-aging effects than DHEA does. Melatonin is known to protect against the most damaging oxidizing agent, known as the hydroxyl radical. According to studies, applying melatonin topically in the form of a cream can help to prevent the skin from damage and aging caused by exposure to ultraviolet rays. Research has shown that free radicals play a role in both acute and chronic skin damage, as well as the efficacy of melatonin in scavenging free radicals. The new Rejuvenex Body Lotion contains melatonin, which helps protect against oxidative damage and maintain more youthful-looking skin when used with vitamin E and alpha-glycolic acid.

Free radicals are harmful molecules that can damage cells, and the skin is particularly susceptible to their effects. Antioxidants are molecules that can neutralize free radicals, and protecting the skin with an antioxidant-rich cream can help to keep it looking young and healthy. The skin is most vulnerable to free radical damage from environmental chemicals, mechanical injury, and UV radiation. The free radicals in skin are also affected by internal oxidizing processes. Melatonin, vitamin E, and alpha-glycolic acid may work together to protect against oxidative damage and help restore more youthful cells to the skin’s surface.


Drinking water alone will not moisturize your skin. It will help to prevent dehydration and decrease blood flow to your skin.

The study divided 128 women over age 40 into three groups based on their genetic risk for skin wrinkles. Lifestyle factors were also evaluated for wrinkle risk.

Participants in the group with more wrinkles, as measured with Mark-Vu, a skin diagnosis system, had these characteristics:

  • Post-menopausal
  • Ate less fruit
  • Took fewer vitamin supplements
  • Exercised less
  • Lower sleep quality
  • UV light exposure

Factors that were found to interact with genetic predisposition and increase wrinkle risk include:

  • Menopause
  • UV light exposure
  • Lower water intake

The researchers found that avoiding exposure to UV light, staying hydrated, and using estrogen after menopause may help reduce the risk of wrinkles in middle-aged women who have a high genetic risk. The results were not enough to change the current practices and did not apply to all women.

The researchers looked at six different studies to see if there might be a connection between how much water someone drinks and how hydrated their skin is. The evidence they found did not support the idea that drinking water has much of an effect on skin hydration. More water intake results in more blood flow to the lower skin layer, but there is not much evidence that it impacts the top layer. They recommend further research.5

Recommendation: Drink plenty of water and stay hydrated. It’s not just good for your skin, it’s good for your overall health.


Retinoids are a powerful source of collagen-producing vitamin A. They produce their effects on the skin by stimulating the growth of collagen and fibroblasts through gene expression. Retinoids also prevent the formation of metalloproteinases, which break down the connective tissue between skin cells.

Retinoids may dry out the skin and may cause redness, irritation, and skin flaking. After two weeks of using the medication daily, the side effects will be at their worst. However, they will gradually get better the more the medication is used. To help reduce side effects, use a lubricating moisturizer with retinoids and slowly increase usage.

Recommendation: Talk to your healthcare provider about retinoids. There are a range of retinoids, with weaker ones available over the counter and stronger ones only available on prescription. This product should be used twice a week for a couple of weeks before increasing use to every other night. Applying the medication only at night and as directed by a healthcare professional will yield the best results.


A humidifier adds moisture to the air. Although increased humidity cannot turn back the clock on skin aging, it can improve the skin’s appearance by preventing dryness and irritation.

When researchers tested skin water loss over six hours in a dry environment, they found an increased risk of fine lines due to dryness.6 When people with sensitive skin were exposed to air with low relative humidity, they noted increased skin roughness after a three-hour exposure.7 Researchers found that when skin is exposed to a dry environment for six hours, it leads to an increased risk of fine lines due to dryness.6 They also found that people with sensitive skin who are exposed to air with low relative humidity tend to have increased skin roughness after just three hours.7

It is recommended to use a humidifier in the winter and when in a dry environment to keep indoor humidity between 30% and 50%. This will improve skin texture and reduce the appearance of fine lines on the skin.


Smoking cigarettes can make your skin look older by causing wrinkles and damage to elastin fibers, which makes skin sag prematurely. People who smoke typically have paler skin with a grayish tinge and more visible skin wrinkling. This is because the nicotine in cigarettes constricts blood vessels, which reduces blood flow and makes skin look paler. The researchers noted that people who smoke have significantly more wrinkles than people who do not, suggesting that smoking is a major factor in the development of wrinkles.

The chemicals in cigarettes enter the bloodstream and cause damage to blood vessels and connective tissue. Since this decreases the amount of nutrients that reach the skin, it also decreases the support for the skin’s structures.

It is recommended that if you are a smoker, you talk to your healthcare provider to get help quitting.


These harmful changes can cause conditions like acne, psoriasis, and eczema. Excessive alcohol consumption can damage the skin’s barrier function and affect its lipid composition, leading to conditions like acne, psoriasis, and eczema. Your skin is your body’s first line of defense against the environment. Lipids are a type of fat that helps to waterproof the skin.

According to researchers, skin aging is directly related to alcohol consumption and tobacco use. If you stop using alcohol and/or tobacco, the changes in your facial skin structure and volume will be reversed.

It is recommended that you reduce or eliminate your alcohol consumption in order to slow down the aging process of your skin.


A multivitamin provides vitamins and minerals that may be lacking in your diet to help maintain overall health. Vitamins can support skin health.9

  • Vitamin D: One of the best sources of vitamin D is sunlight. Just 20 minutes of sun exposure two to three times a week may be enough. Check with your doctor first if you are at an increased risk of skin cancer. You can also get vitamin D in your multivitamin or your diet. Vitamin D can help protect against atopic dermatitis and other skin conditions. It also reduces skin damage and inflammation.10
  • Vitamin C: A potent antioxidant, vitamin C protects your skin against oxidative damage from free radicals and helps with collagen production.11
  • Vitamin E and Vitamin A: Vitamins E and A are also potent antioxidants. These antioxidants can protect your skin from sun damage. Vitamin A also regulates the expression of genes and protects the matrix that binds skin cells together.12
  • B-complex vitamins: B-complex vitamins can help reduce inflammation and changes in skin pigmentation.12

The best way to get a full range of vitamins, minerals, and nutrients is by eating a varied diet. This means eating a variety of different kinds of foods from all the food groups. If you’re not getting enough of certain vitamins from your diet, you might want to take a multivitamin supplement. Vitamin deficiency affects skin health.


Although our articles and guides are accurate and current, they should not be used as a replacement for medical advice from a doctor or healthcare provider. You should always get a professional opinion to see what is wrong. The information in this guide is for informational purposes only and does not constitute medical advice.


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