The Biggest Mistakes of Autophagy and Fasting

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Are you trying to get autophagy? You should but what about the mistakes of autophagy? Read this article about autophagy mistakes first.

Trying to Get Autophagy?

Autophagy appears to be a formerly neglected aspect of health and long life that is gaining more attention due to intermittent fasting.

Autophagy can be promoted in a number of methods, however, fasting and lowered caloric intake are thought to be the most dependable and successful strategies. This causes a lack of essential nutrients and creates an energy deficit which encourages the reuse of old cells.

We are not able to directly monitor autophagy in humans, yet we are aware that inadequate insulin levels, not enough amino acids, and sugar levels that are too low impede mTOR activity, which in turn favors autophagy. Elevated AMPK also promotes this process.

Mistakes of Autophagy

Though plenty of research remains on autophagy and its operations, we can still determine certain facts and discern which errors to steer clear of when attempting to attain autophagy.

  • Spiking insulin and raising blood sugar stop autophagy.
  • High amounts of nutrients stop autophagy.
  • Fasting and not eating promote autophagy.
  • Keeping lower insulin to glucagon ratio promotes autophagy.
  • Eating less frequently promotes autophagy.

It would be unfortunate to put in a lot of work on intermittent fasting and then disrupt the autophagy process by mistake. That’s quite common, actually.

Here is a list of the biggest errors you should attempt to evade if your intention is to acquire the rejuvenating and longevity-promoting benefits of fasting through autophagy.

#1 Not Fasting Long Enough

It is suggested that to start off with autophagy, you ought to abstain from food for three to five days; however, this can vary a lot depending on the balance of mTOR and AMPK specific to each person.

The general consensus is that engaging in intermittent fasting for around 12-16 hours can jumpstart autophagy, eliminate any cancer cells in the body, push growth hormone levels to a high level, stimulate stem cell production, and potentially make you superhuman.

Unfortunately, not refraining from eating for 16 hours does not put one into a true state of fasting. Here’s why:

  • You don’t start fasting immediately after finishing your last meal because you need to first digest the nutrients you ate.
  • The post-absorptive state of metabolism lasts about 4 hours after the meal you’ve eaten.

It is true that you do not enter the fasting state until five or six hours after ceasing to eat. During this stretch of time, you’re still using the calories from the last meal you ate.

Going on a 16 to 20-hour fast means that you would only be in a fasting state for around 12 hours, which may not be long enough to kick-start autophagy.

To create substantial autophagy, fasting for more than 24 hours and ideally up to 3-5 days is recommended.

#2 Fatty Coffee

It is accurate to say that while fat does not have the same effect on insulin levels as either carbs or protein, it will still activate mTOR and put the body into a fed state.

Ketone bodies are able to activate chaperone-mediated autophagy and macroautophagy in the brain, however, this would typically generally happen only when a person is starving. You can achieve similar results when you implement a ketogenic diet and add a small amount of MCT oil to your coffee.

Although a considerable amount of calories from fat will not break a fast, an excessive amount of calories from fat will ultimately lead to increasing mTOR and insulin levels. You should not exceed one teaspoon of ketone-boosting fats.

If you want to guarantee autophagy is triggered, then abstain from consuming any calories. Putting MCT oil in your coffee may be viable for sustaining extended periods of fasting and providing energy to persist on demanding fasts, but it is not advised.

#3 BCAAs

Branch-Chain Amino Acids are made entirely of amino acids, which will quickly halt autophagy.

Many people utilize BCAAs out of worry that they may lose muscle, but those concerns are unfounded. Ketosis and severe abstaining from food have an effect that prevents muscle breakdown due to having more ketone bodies and a heightened amount of growth hormone.

Ingesting BCAAs may actually trigger your body to become more catabolic since it will disrupt ketosis and prevent autophagy. Research indicates that taking BCAAs may be associated with disruptions in neurotransmitter activity and the development of mood disorders. That’s why I’d stay away from them.

You can only consume BCAAs when you exercise on an empty stomach, which helps activate mTOR and protein production.

#4 Artificial Sweeteners

Sweeteners that don’t contain any calories cause an increase in insulin levels by triggering the cephalic phase response, which signals the body to release insulin into the digestive system.

The mere sight, smell, thought, and taste of food can get your appetite going, causing your body to produce gastric juices and insulin as a response even before you have taken a bite. You experience a sugary taste in your mouth, prompting your stomach to get ready to take in the nutrients by sending out insulin beforehand.

Certain artificial sweeteners such as aspartame, saccharin, and sucralose can cause an increase in insulin and blood sugar levels in certain individuals, while having no effect on others. Things like stevia and erythritol also have mixed results.

You must be aware of what effect sweeteners have on your own blood sugar amount and the way it affects you psychologically. Despite this, artificial sweeteners are likely to interfere with the process of autophagy and also destabilize the gut microbiome.

#5 Supplements with Calories

There are lots of supplements that can ruin a fast since they contain calories and excess sugar. Others tend to have no effect and are safe. Furthermore, their caloric content of them is quite minimal.

A vitamin D or krill oil pill contains a very small quantity of fat, usually not enough for one or two servings to disrupt a fast or prevent autophagy. Similarly, some herbs such as turmeric, berberine, and mushroom complex do not have a considerable impact. They may actually support fasting.

If you consume various dietary supplements, the accumulated calories will be enough to terminate fasting. I would advise against consuming any supplements while fasting.

A period of less than 5-7 days does not necessitate the taking of nutritional supplements and will not be lacking in vital nutrients. You might want to consider bringing potassium chloride and magnesium with you.

#6 Circadian Rhythm Mismatches

Most autophagy gets activated during deep sleep. Growth hormone is mainly released during the hours of 11 PM to 2 AM.

It is advisable to set a bedtime earlier and put emphasis on the initial part of your sleep if you’d like to maximize autophagy because that is when the majority of physical restoration transpires.

It doesn’t make a difference how long you practice fasting or how few calories you consumers if your sleep is of poor quality. Most of the advantages of abstaining from food, such as autophagy and growth hormone, are activated while sleeping, making it a vital component of keeping good health.

Fasting Mistakes and How to Avoid Them

1. You’re Snacking or “Grazing.”

The point of a fast is to limit your consumption of food to particular times. Consuming snacks consistently throughout the day is not equivalent to fasting, so I don’t think that this will be a suitable substitute. Fasting is “on” or “off”—there is no gray area. No matter how minuscule or healthy the portion is, consuming anything while in a fasted state will generally halt any healing that is taking place and prevent the advantages of fasting from manifesting. This also produces a state wherein the insulin is being generated by your body throughout the day. Bad idea.

Keep snacks and food hidden to refrain from snacking. The concept of “forgotten if not seen” is especially relevant in this case. It will astound you how much more straightforward it is to avoid snacking if the food is not in view. If you are in the habit of snacking, think of ways to get imaginative and identify new activities which do not involve food. If you are snacking due to legitimate hunger, you might need to reconsider the meals you consume in the course of the time frame you have set for food consumption. Be sure to include a sufficient amount of oils and other sources of unsaturated fats each time you eat, as these will stave off hunger longer.

2. You Aren’t Drinking Enough Water

No matter what type of eating regimen someone follows, this misstep is one that the majority of people tend to make. It is important to consume at least eight cups of water each day in order to stay hydrated and in good health. Evidence that you may not be taking in enough fluids could be lightheadedness and dizziness, feeling drained, or difficulty with bowel movements.

It can be even worse when you don’t take in adequate amounts of water, as your brain might attempt to deceive you into believing that you are hungry when you are, in fact, lacking nutrients. Your brain health requires minerals like potassium and magnesium. Don’t be taken aback the subsequent time you get famished but find that gulping a glass of water vanishes the hunger. Different types of tea can be a beneficial way to get fluids, or alternatively, consume bone broth if it is difficult for you to stay hydrated.

3. You Aren’t Consuming Enough Salts

Mentioning vitamins and minerals brings up the importance of consuming the right amount of salt for good well-being. When I mention “salt,” I am not referring to table salt. I am referring to electrolytes, which are needed to maintain a healthy diet. A common electrolyte that many people know of is sodium or table salt (Na), alongside others such as potassium (K), magnesium (Mg), calcium (Ca), and chloride (Cl).

How can you tell if you’re low on electrolytes? Some indications of a lack of electrolytes may involve being nervous, easily irritated, having difficulty sleeping, cramping, feeling exhausted, abdominal distress, and wooziness. If you are having these kinds of signs and symptoms while fasting, it could be due to an electrolyte deficiency. Put a pinch of pink Himalayan rock salt under your tongue and let it dissolve. You may want to experiment with drinking pickle juice, but make sure to choose a good source. Preferably one that doesn’t contain sugar.

4. You’re Eating Right Before You Go To Sleep

It is important to give your body a chance to process the food you just ate before you hit the hay. If you eat before bedtime, your body will be spending the time that ought to be set aside for resting to digest food instead. You will require a lot of energy, and you won’t wake up feeling refreshed and prepared to start the day; you’ll just be drained.

When adhering to a fasting schedule, having a seven-hour interval between your final meal and bedtime is optimal. It doesn’t take a long time to make an impact – even a small amount of time can be beneficial. Due to the hectic timetables and having to get up early, several individuals struggle to maintain the recommended three or four-hour duration. Come back home, devour dinner, and head directly to sleep. If this situation applies to you, then it is advisable to have a light meal, such as a salad, and abstain from a dish that is composed mainly of carbs and protein.

5. You’re Eating Too Much of Some Food Groups

When we eliminate specific types of food, particularly carbohydrates, from our eating habits, it’s simple to depend on other nutritional categories, like nuts and dairy products. They’re readily available and a staple of most diets.

Small portions of nuts are an excellent source of low-carb, healthy fats. These snacks are perfect to augment fruit or vegetable salads, and they are simple to take when a speedy snack is wanted. Snacking can be a real drain on your diet if consumed in excess, particularly when eaten in addition to regular meals. Nuts contain beneficial fats, few carbohydrates, and a moderate amount of protein. However, an overabundance of protein can be detrimental to your diet. If the body does not require any more protein than what it needs, the unused protein will be changed into glucose and will be retained as fat. Fasting to slim down is the exact opposite of the desired result.

Many individuals avoid dairy too often, yet it can be a source of inflammation, queasiness, swelling, flatulence, and other kinds of discomfort if you have recognized that your physical health and nutrition choices are interconnected, experiment by avoiding dairy products for a few weeks and notice whether your symptoms have improved. Pay attention to any changes in your eating habits and take note of how your body responds after consuming dairy products.

6. You Aren’t Eating Enough of Certain Food Groups

It is as simple to consume an excessive quantity of a single food group as it is to not get a sufficient amount of another. Despite the fact that you may have the option to consume whatever you wish during your designated time for meals, it does not indicate that you should. Foods with little or no nutritional value may give a short-term pleasure boost, but they won’t provide lasting energy to your body. If you consume the correct types of food, it will give your body the nourishment it requires to stay healthy during the day; these meals will also make you feel full for an extended period of time.

Eating veggies is an excellent way to ensure that your body is well-nourished and in optimal condition. They offer few calories but still supply essential nutrients like potassium, fiber, folate, vitamin A, and vitamin C. Fruits are good for you, but be sure not to eat too much of them, as wide varieties have a high amount of sugar. Fruit juices typically have added sugar as well. Naturally flavored drinks and teas are the healthiest option. Nuts are loaded with fat and provide a good quantity of protein, the same being true for eggs. You do not need altered carbs and sugars in your diet, and if you are going to eat them, they should be in minimal amounts.

Avoid These Autophagy Mistakes

There is no definitive answer as to how autophagy behaves in different people, as it will differ depending on the metabolic condition of the individual.

The safest way to prevent any problems with autophagy is to regularly fast, exercise, maintain healthy circadian rhythms, and eat nutritious foods.


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