Is It Safe to Stay in Ketosis All the Time?

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Some individuals may find that a keto regimen can be effective in reducing body fat and decreasing inflammation over a limited period of time. For others, it’s a permanent lifestyle.

No matter how devoted you are, it is highly probable that you have thought about stopping your keto diet for a period of time. Maybe you have even eaten some cheat meals recently.

Could you be pondering whether you need to remain in ketosis consistently to keep the weight off? What will occur if you attain your well-being objectives with a keto diet and then start consuming carbs again?

Effects of Ketosis

Ketosis is an intriguing metabolic circumstance where the body primarily uses fat and ketones as energy sources rather than glucose. Reaching your dietary goals can be accomplished by cutting down on carbohydrate consumption or going through long periods of not eating. The body begins to transmute fat into ketones for energy for the mind and other organs once the liver’s glycogen stores have been depleted.

A heightened level of ketones provides many positive outcomes, such as decreased inflammation, protection against seizures, steady glucose levels, antioxidizing agents such as glutathione and Nrf2, decreased hunger, and an increasing amount of NAD. Studies have indicated that the ketogenic diet can positively alter the microbiome by reducing ROS production, leading to weight loss and reduced lactate levels. However, it has been noted that this particular diet can also lower both alpha diversity and richness of gut bacteria.

For more than seven decades, ketogenic diets have been used to treat disorders such as epilepsy, diabetes, cancer, and neurodegenerative illnesses like Alzheimer’s and Parkinson’s. Unfortunately, children who receive treatment with the ketogenic diet for epilepsy display elevated levels of arterial tightness. The research done on those with epilepsy who receive keto treatments reveals that those individuals tend to quit the keto diet after about six years and keep the same level of seizure control as well as normal lipid levels.

Nevertheless, being in a state of ketosis for a prolonged period of time or being exposed to high levels of tension can lead to unfavorable results. Be advised: In my opinion, a cyclic ketogenic diet offers more advantages in terms of adjusting metabolism and overall health in the long run. I’m going to explain and give some examples now.

Ketosis Cardiac Fibrosis

In cultivated cells and in animals used in experiments, a prolonged ketogenic diet produces a build-up of beta-hydroxybutyrate (B-OHB). This is linked to cardiac fibrosis and a reduction in the formation of mitochondria. Lab rats are given a meal plan that primarily consists of soybean oil and cocoa butter to induce ketosis; however, such nutrition can result in inflammation and is known to have a higher potential of causing heart disease. Fats that cause irritation and packing on the pounds, in and of themselves, can lead to fibrosis and atherosclerosis regardless of your ketosis status.

Studies have indicated that beta-hydroxybutyrate has properties that inhibit inflammation, slow the aging process, and protect against the damage caused by oxidation. Studies have demonstrated that following a ketogenic way of eating can reverse indicators associated with heart disease in mice that have hereditary deficiencies. Research has shown that the keto diet can help increase the production and efficiency of mitochondria by amplifying the levels of molecules such as sirtuins and PGC1alpha.

Individuals suffering from arterial fibrillation and hemodialysis tend to have higher levels of B-OHB. However, correlation does not mean causation. Beta-hydroxybutyrate levels could be elevated in persons with a health disorder due to the body not utilizing ketones for energy and thus not making them ill. Diabetic ketoacidosis is an example of a medical condition that is marked by elevated ketone levels and elevated blood glucose as a result of insulin resistance. The organism is not utilizing ketones as fuel because of the elevated level of glucose in the bloodstream.

People with diabetes and who have difficulty controlling their blood sugar levels are more likely to experience arterial fibrillation. Diabetics possess an excessive concentration of ketones alongside an abnormally high sugar level in the blood. An individual not suffering from diabetes but who is in extreme ketosis is unlikely to suffer the negative consequences due to the fact that diabetes is more likely to bring on arrhythmia than the benefits of beta-hydroxybutyrate, which have protective and anti-inflammatory qualities. It is essential to identify how ketosis is accomplished using different kinds of food and under different circumstances.

Does Keto Cause Insulin Resistance

A two-week ketogenic diet was given to overweight people with diabetes, which resulted in a 30% decrease in daily calorie consumption and a weight loss of approximately 1.65 kg. It also drastically improved insulin sensitivity by 75% and caused a decrease in triglycerides and cholesterol levels between 10-35%. It is possible that some of the results are due to the fact that the test subjects were consuming fewer calories than they usually do, with a deficit of 1000 calories. In a 2009 study, the calorie content was the same for three different groups over a period of eight weeks. The percentage of fat loss wasn’t significant between them. Nevertheless, the results varied regarding fasting blood insulin levels and blood glucose after a meal. Researchers concluded that diets that contain the same amount of calories with very few carbohydrates could improve triacylglycerols, HDL cholesterol, and insulin resistance.

A 2018 examination contended that ingesting a ketogenic eating routine for brief timeframe results in greater serious hepatic insulin obstruction contrasted with an obesogenic high-fat eating regimen. During the period of not having eaten, the mice on the ketogenic diet were found to have healthier metabolic systems, but the ones that were given high-fat, unhealthy food had elevated levels of insulin. The glucose test revealed that both mice consuming a ketogenic diet and those eating high-fat processed food were unable to tolerate glucose. The amount of glucose taken up by muscles and other tissues stayed the same. Insulin had its production hindered due to elevated levels of fat burning, which prevented insulin from diminishing the amount of sugar in the blood. The researchers discovered that the insulin resistance found in the ketogenic mice is probably not caused by any harm and is able to be reversed. These mice did not suffer from diabetes; they were only not prepared to make use of glucose since their body was breaking down fat. If the same mice took a glucose tolerance test at a later date, they would have an improved capacity to assimilate that glucose, as their body has already become adapted to no longer being in a state of ketosis. A research experiment that lasted 8 weeks and involved ketogenic mice revealed that their sugar levels dropped after eating a meal with a lot of carbohydrates; however, the results quickly returned to normal when the creatures returned to their typical diet. The same phenomenon occurs in humans.

If you don’t have carbohydrates in your diet for a certain period of time, then your body will reduce the level of insulin it produces since it is no longer needed. This is a temporary adjustment prompted by increased lipid catabolism that prefers fats for energy rather than carbs. It could possibly be called insulin resistance, though none of the typical signs and symptoms like increased fasting insulin, increased blood glucose levels, or high triglyceride levels would be present. Using different words, a possible paraphrase of the sentence could be: “It might be more precise to describe it as “lowering of glucose requirement” or “saving of glucose” because that is the phenomenon that is taking place.”

Is Ketosis Safe Long Term?

If you have experienced success on the keto diet and feel better than you ever have, you may not be inclined to discontinue the diet.

Here’s what studies tell us about the safety of longer periods of ketosis:

There are “beneficial effects to a long-term keto diet

The results of an analysis done over a period of 6 months in 2004 involving overweight patients showed positive effects of an extended keto diet.

The patients experienced a notable decrease in their body weight and body mass index. In addition, there was a decrease in triglycerides, LDL cholesterol, and blood glucose levels and an elevation of HDL cholesterol.

No major adverse reactions were noted in the patients over a prolonged period of time while they were being given a ketogenic diet. Thus, this research endorses that it is safe to have a ketogenic diet for a duration of time that is longer than what was originally thought. (Emphasis added).

No adverse effects

The findings of a study into the influence of a low-carb, high-fat diet on cardiovascular health, published in 2015, established that body weight and risk factors were lowered without causing any serious side effects. Additionally, all of the study’s targets were met.

A 2017 year-long randomized clinical trial of people with type 2 diabetes contrasted a moderate-carb eating regimen against a low-carb keto diet and found that those on the keto diet lost in excess of double the amount of weight, and some members of the keto group could safely stop taking their diabetes medications. The authors did not record any serious adverse effects.

Staying keto for a year is safe.

An experiment with a duration of one year that was published in 2018 studied the contrast between an unhealthy low-carb meal plan and a low-fat diet with overweight adults and found the ratio of unplanned events (less than 3%) that were likely not connected with the diets was even in both groups. Put differently, continuing with the ketogenic diet for 12 months was just as safe or even safer than not adhering to it.

The conclusion drawn is that nutritional ketosis has not proven to be hazardous in the present nor in the future and has consequently been found to be beneficial to people who consistently adhere to the diet.

Certain medical professionals and nutritionists have expressed worry about potential nutrient shortages, inadequate fiber consumption, or other difficulties as a result of a low-carb diet.

It must be remembered that while protein and fat are essential macronutrients, carbohydrates do not have to be consumed. As long as you consume nutritious, low-carb unrefined foods, the keto diet is just as healthy as any other eating plan.

How to Reincorporate Foods Back into Your Diet

The keto diet is extraordinary compared to other eating regimens since it necessitates abstaining from almost all carbohydrates. It is advisable to proceed with caution if you choose to stop following the keto diet, taking it to step by step.

A gradual move away from the keto diet can help to evade issues such as pigging out or regaining weight quickly and, at the same time, evaluate how your body responds.

Here’s how to do it:

  • Stick with healthy, organic whole foods whenever possible: Keto or not, you need to eat healthy foods to stay healthy. Choose wisely.
  • Record your macros and increase carbs incrementally over a period of a few months. Try adding in around 50-75 grams of daily carbs each week at most. After strict keto, your body needs time to readjust.
  • Weigh in regularly and track your results: During and after your transition, pay close attention to the areas in which you noticed improvement during keto. Bodyweight, body fat percentage, blood sugar, and physical performance are measurable, so remember to monitor them about once a week.
  • Listen to your body: Outside of quantifiable health markers, there are plenty of other important outcomes that affect your quality of life. Check in and notice your mood, energy levels, sleep quality, productivity, and stress levels.
  • Make adjustments when necessary: Depending on your results, you may want to adjust your macros, calories, or food selection–or even return to a keto diet.

And avoid these mistakes:

  • Don’t make up your mind ahead of time: Instead of being inflexible, keep an open mind as to what may happen next. View going off keto as an experiment and learning process.
  • Avoid the “cheating” mindset: You most likely didn’t binge eat on keto, and you certainly shouldn’t overindulge on carbs or junk food if you stop keto. Keep a healthy, balanced mindset around food.
  • Don’t neglect high-quality protein and healthy fat sources: Whether or not you stay keto, eating plenty of protein and healthy fats are essential for a healthy diet.

If you have signs of irritable bowel syndrome or other digestive problems, investigate particular foods more carefully.

Keto is sometimes used in the same way people use elimination diets to find out which foods cause sensitivities; if you begin eating carbs again, you may accidentally reintroduce something that causes a reaction.

Compare how you feel following the keto diet to what you experienced before you began it. It won’t take long to identify the things that are beneficial and not beneficial for your body – it could take anywhere from a few weeks to a few months.

Should You Stay in Ketosis All the Time

It is difficult to know what the effects of continuously being in a state of ketosis for extended periods will be, as there are few individuals who have maintained it for a considerable amount of time. I have been adhering to a cyclic ketogenic diet for five or more years now. I had gone through times when I strictly kept to a low-carb diet for multiple months; however, most of the time, I had carbs at least one or two times a week. I have been able to take advantage of both dietary approaches by utilizing this plan.

Ketosis is an invaluable resource that you can take advantage of, but it is not an absolute requirement for achieving peak wellness. A person with good health should occasionally experience a state of ketosis following an overnight fast, which is a sign that their body is not excessively in a high-sugar state and is able to adjust to changes in dietary energy sources.

Being taken out of ketosis doesn’t have to mean consuming a whole packet of crisps or a whole box of doughnuts. One’s body would not be able to process so many carbs, and it would leave one feeling horrible and experiencing a significant spike in blood sugar. Instead of making drastic changes to your diet, simply increasing your intake of either protein or vegetables will accomplish the same results.

The Takeaway: Make Keto Work for You

The keto diet can be an incredibly effective means of promoting health, whether it’s used for a limited period of time or kept up as a long-term lifestyle.

It is not obligatory to continue following the ketogenic diet permanently, yet a great many people make a decision to, and it appears to be a safe option.

High fat burning, suppressed cravings, and a surge of energy can make it simpler to remain healthy and slim.

If you want to try alternative diets and they don’t yield the desired results, you can always revert back to the keto diet in the future.


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